Zebrafish Melanophores Suggest Novel Functions of Cell Chirality in Tissue Formation

Several types of cells show left–right asymmetric behavior, unidirectional rotation, or spiral movements. For example, neutrophil-like differentiated HL60 (dHL60) leftward bias in response to chemoattractant. Neurons extend neurites, creating a clockwise spiral. Platelet shows arrangements actin fibers. In the microfabricated culture environment, groups C2C12 (mouse myoblast cell line) were autonomously aligned counter-clockwise pattern, and isolated showed pattern skeleton. This biased directionality suggested that these have inherent chirality. addition cells, we recently found melanophores zebrafish also an intrinsic cellular chirality was shown by their self-rotation. Although this is obvious, function still unclear. review, compare with other consider morphogenesis.